Genetically Engineered Peptides for Inorganics: Study of an Unconstrained Bacterial Display Technology and Bulk Aluminum Alloy

نویسندگان

  • Bryn L Adams
  • Amethist S Finch
  • Margaret M Hurley
  • Deborah A Sarkes
  • Dimitra N Stratis-Cullum
چکیده

The first-ever peptide biomaterial discovery using an unconstrained engineered bacterial display technology is reported. Using this approach, we have developed genetically engineered peptide binders for a bulk aluminum alloy and use molecular dynamics simulation of peptide conformational fluctuations to demonstrate sequence-dependent, structure-function relationships for metal and metal oxide interactions.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Molecular biomimetics: nanotechnology through biology.

Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed by using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically ...

متن کامل

Microbial Cell Surface Display: Its Medical and Environmental Applications

Cell-surface display is the expression of peptides and proteins on the surface of living cells by fusing them tofunctional components of cells which are exposed to the environment of cells. This strategy can be carriedout using different surface proteins of cells as anchoring motifs and different proteins from different sourcesas a passenger protein. It is a promising strategy...

متن کامل

Enhanced Bioadsorption of Cadmium and Nickel by E. coli Displaying A Metal Binding Motif Using CS3 Fimbriae

Display of peptides on the surface of bacteria offers many new and exciting applications in biotechnology. Fimbriae is a good candidate for epitope display on the surface of bacteria. The potential of CS3 fimbriae of enterotoxigenic E. coli as a display system has been investigated. A novel cell surface display system with metal binding property was developed by using CS3 fimbriae. Short metal ...

متن کامل

Design and bioinformatics analysis of novel biomimetic peptides as nanocarriers for gene transfer

Objective(s): The introduction of nucleic acids into cells for therapeutic objectives is significantly hindered by the size and charge of these molecules and therefore requires efficient vectors that assist cellular uptake. For several years great efforts have been devoted to the study of development of recombinant vectors based on biological domains with potential applications in gene therapy....

متن کامل

EFFECT OF THE INCLINED COOLING PLATE CHARACTERISTICS ON THE THIXOTROPIC MICROSTRUCTURE OF A356.0 ALUMINUM ALLOY

In the present work microstructural evolution of A356 Aluminum alloy using an inclined cooling plate casting process for thixoforming feedstock production is investigated. The resultant microstructure was evaluated and compared with those of the same alloy produced by the conventional casting process, i.e. directly cast in the same mold without using an inclined cooling plate. It was found that...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 25  شماره 

صفحات  -

تاریخ انتشار 2013